The Endocannabinoid System
Introducing the ECS
The Endocannabinoid System (ECS) is a biological system made up of a network of receptors and transmitters throughout your body that plays an integral part in regulating our physiology and maintaining homeostasis. The entire system is made up of cannabinoid receptors, endocannabinoids and metabolic enzymes. Phytocannabinoids, like CBD, help our bodies remain in balance.
Cannabinoids & the ECS
The two major cannabinoid receptors in our ECS are our CB1 and CB2 receptors. CB1 receptors are primarily found in the brain and central nervous system and CB2 receptors are primarily found in our peripheral organs. Cannabinoids can directly affect our ECS by binding to receptors. THC, for example, binds directly to our CB1 receptors and is known for its strong psychoactive effects. CBD, however, has low affinity to our CB1 and CB2 receptors, meaning that its impact on the ECS is driven indirectly.
TRVP1: CBD binds to our TRVP1 receptors, which are commonly known for managing our perception of pain, inflammation and temperature.
TRVP2: CBD binds to our TRVP2 receptors, which play an integral role in neuronal development, heart function, immunity and cancer.
GPR55: CBD is an antagonist to our GPR55 receptors, meaning it blocks GPR55 activity. GPR55 has been associated with seizures, cancer, obesity and diabetes.
GPR119: CBD’s interaction with GPR119 is still being further researched.
GPR18: CBD is an antagonist to our GPR18 receptors, which may prevent endometrial cells from migrating.
5HT1A: CBD directly interacts with our 5HT1A receptor, which is a serotonin receptor, known for its role in how we feel.